Rheumatoid Factors (RF)
Rheumatoid factors are autoantibodies (IgM, IgG)
directed against the Fc-part of human IgGs. High titres of rheumatoid factors
are found in different rheumatoid and non-rheumatoid diseases. Higher titres of
rheumatoid factors are more common in patients with rapidly progressive joint
destruction and in those with extraarticular manifestations such as
subcutaneous rheumatic nodules. Positive rheumatoid factors are also seen in
autoimmune rheumatic diseases and in non-rheumatic conditions with variable
frequency e.g. SLE, Sjögren’s syndrome, subacute bacterial endocarditis and
other bacterial infections, infectious hepatitis, chronic liver diseases,
chronic active pulmonary diseases, parasitic infections and viral infections.
Rheumatoid factors should not be the only criteria in the diagnosis of
rheumatoid disease but be considered in conjunction with clinical symptoms.
Immunoturbidimetric test for the quantitative
determination of rheumatoid factors (IgM) in human serum.
Latex enhanced immunoturbidimetric method
Kit name Reagent
type Size
Rheumatoid Factors (RF) System reagent 1 x
100